UBE2S antibody (AA 1-222)

Catalog No. ABIN7174484

This Rabbit Polyclonal antibody specifically detects UBE2S in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for UBE2S antibody (AA 1-222) (ABIN7174484)

Target: UBE2S (Ubiquitin-Conjugating Enzyme E2S (UBE2S))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2S antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-UBE2S Antibody

Binding Specificity: AA 1-222

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 S protein (1-222AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBE2S

Target: UBE2S (Ubiquitin-Conjugating Enzyme E2S (UBE2S))

Alternative Name: UBE2S

Background:

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes \\\'Lys-11\\\'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating \\\'Lys-11\\\'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro, it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except \\\'Lys-48\\\'-linked polyubiquitination.

Aliases: AA409170 antibody, E2 EPF antibody, E2-EPF antibody, E2EPF antibody, EPF5 antibody, MGC101982 antibody, Ube2s antibody, UBE2S_HUMAN antibody, Ubiquitin carrier protein S antibody, Ubiquitin conjugating enzyme E2 24 kD antibody, Ubiquitin conjugating enzyme E2 24 kDa antibody, Ubiquitin conjugating enzyme E2 EPF5 antibody, Ubiquitin conjugating enzyme E2 S antibody, Ubiquitin conjugating enzyme E2S antibody, Ubiquitin protein ligase S antibody, Ubiquitin-conjugating enzyme E2 S antibody, Ubiquitin-conjugating enzyme E2-24 kDa antibody, Ubiquitin-conjugating enzyme E2-EPF5 antibody, Ubiquitin-protein ligase S antibody

UniProt: Q16763

Pathways: Ubiquitin Proteasome Pathway