UBA1 antibody (AA 730-881)

Catalog No. ABIN7174520

This Rabbit Polyclonal antibody specifically detects UBA1 in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for UBA1 antibody (AA 730-881) (ABIN7174520)

Target: UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-UBA1 Antibody

Binding Specificity: AA 730-881

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-like modifier-activating enzyme 1 protein (730-881AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBA1

Target: UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))

Alternative Name: UBA1

Background:

Background: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).

Aliases: A1S9 antibody, A1S9 protein antibody, A1S9T and BN75 temperature sensitivity complementing antibody, A1S9T antibody, A1ST antibody, AMCX1 antibody, CFAP124 antibody, CTD-2522E6.1 antibody, GXP 1 antibody, GXP1 antibody, MGC4781 antibody, POC20 antibody, POC20 centriolar protein homolog antibody, Protein A1S9 antibody, SMAX2 antibody, Uba1 antibody, UBA1, ubiquitin-activating enzyme E1 homolog A antibody, UBA1_HUMAN antibody, UBA1A antibody, UBE 1 antibody, UBE 1X antibody, UBE1 antibody, UBE1X antibody, Ubiquitin activating enzyme E1 antibody, Ubiquitin-activating enzyme E1 antibody, Ubiquitin-like modifier-activating enzyme 1 antibody

UniProt: P22314