RAD23A antibody (AA 2-201) (Biotin)

Catalog No. ABIN7175171

This Rabbit Polyclonal antibody specifically detects RAD23A in ELISA. It exhibits reactivity toward Human.

Quick Overview for RAD23A antibody (AA 2-201) (Biotin) (ABIN7175171)

Target: RAD23A (RAD23 Homolog A (RAD23A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD23A antibody is conjugated to Biotin

Application: ELISA

Product Details anti-RAD23A Antibody (Biotin)

Binding Specificity: AA 2-201

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human UV excision repair protein RAD23 homolog A protein (2-201AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RAD23A

Target: RAD23A (RAD23 Homolog A (RAD23A))

Alternative Name: RAD23A

Background:

Background: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to \\\'Lys-48\\\'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to \\\'Lys-63\\\'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.

Aliases: hHR 23A antibody, hHR23A antibody, HR23A antibody, MGC111083 antibody, RAD 23a antibody, RAD23 homolog A (S. cerevisiae) antibody, RAD23 homolog A antibody, RAD23 yeast homolog A antibody, RAD23A antibody, RD23A_HUMAN antibody, UV excision repair protein RAD23 antibody, UV excision repair protein RAD23 homolog A antibody

UniProt: P54725

Pathways: DNA Damage Repair