VPS26B antibody (AA 1-336)

Catalog No. ABIN7175296

Product Details anti-VPS26B Antibody

Target: VPS26B (Vacuolar Protein Sorting 26 Homolog B (VPS26B))

Binding Specificity: AA 1-336

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS26B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 26B protein (1-336AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VPS26B

Target: VPS26B (Vacuolar Protein Sorting 26 Homolog B (VPS26B))

Alternative Name: VPS26B (VPS26B Products)

Synonyms: VPS26B antibody, wu:fb49d07 antibody, wu:fb50d06 antibody, zgc:56297 antibody, pep8b antibody, vps26b antibody, Pep8b antibody, VP26B antibody, 1810012I05Rik antibody, 2310075A12Rik antibody, AI848392 antibody, T29A15.180 antibody, T29A15_180 antibody, vacuolar protein sorting 26B antibody, vacuolar protein sorting 26 homolog B (S. pombe) antibody, VPS26, retromer complex component B antibody, VPS26 retromer complex component B antibody, VPS26 retromer complex component B S homeolog antibody, vacuolar protein sorting 26B antibody, VPS26B antibody, vps26b antibody, vps26b.S antibody, Vps26b antibody

Background:

Background: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

Aliases: Pep8b antibody, Vacuolar protein sorting 26 homolog B (S. pombe) antibody, Vacuolar protein sorting 26 homolog B (yeast) antibody, Vacuolar protein sorting-associated protein 26B antibody, Vesicle protein sorting 26B antibody, VP26B_HUMAN antibody, VPS26B antibody

UniProt: Q4G0F5

Pathways: Cellular Glucan Metabolic Process