WDFY3 antibody (AA 1-100)

Catalog No. ABIN7175699

This Rabbit Polyclonal antibody specifically detects WDFY3 in ELISA, IF and IHC. It exhibits reactivity toward Human.

Quick Overview for WDFY3 antibody (AA 1-100) (ABIN7175699)

Target: WDFY3 (WD Repeat and FYVE Domain Containing 3 (WDFY3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDFY3 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-WDFY3 Antibody

Binding Specificity: AA 1-100

Purpose: WDFY3 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WDFY3

Target: WDFY3 (WD Repeat and FYVE Domain Containing 3 (WDFY3))

Alternative Name: WDFY3

Background:

Background: Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.

Aliases: WDFY3 antibody, KIAA0993 antibody, WD repeat and FYVE domain-containing protein 3 antibody, Autophagy-linked FYVE protein antibody, Alfy antibody

UniProt: Q8IZQ1