WDFY3 antibody (AA 1-100) (Biotin)

Catalog No. ABIN7175700

The Rabbit Polyclonal anti-WDFY3 antibody has been validated for ELISA. It is suitable to detect WDFY3 in samples from Human.

Quick Overview for WDFY3 antibody (AA 1-100) (Biotin) (ABIN7175700)

Target: WDFY3 (WD Repeat and FYVE Domain Containing 3 (WDFY3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDFY3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-WDFY3 Antibody (Biotin)

Binding Specificity: AA 1-100

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WDFY3

Target: WDFY3 (WD Repeat and FYVE Domain Containing 3 (WDFY3))

Alternative Name: WDFY3

Background:

Background: Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.

Aliases: WDFY3 antibody, KIAA0993 antibody, WD repeat and FYVE domain-containing protein 3 antibody, Autophagy-linked FYVE protein antibody, Alfy antibody

UniProt: Q8IZQ1