WIPI1 antibody (AA 187-446)

Catalog No. ABIN7175707

This anti-WIPI1 antibody is a Rabbit Polyclonal antibody detecting WIPI1 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for WIPI1 antibody (AA 187-446) (ABIN7175707)

Target: WIPI1 (WD Repeat Domain, phosphoinositide Interacting 1 (WIPI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WIPI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-WIPI1 Antibody

Binding Specificity: AA 187-446

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human WD repeat domain phosphoinositide-interacting protein 1 protein (187-446AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WIPI1

Target: WIPI1 (WD Repeat Domain, phosphoinositide Interacting 1 (WIPI1))

Alternative Name: WIPI1

Background:

Background: Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

Aliases: ATG 18 antibody, ATG18 antibody, Atg18 protein homolog antibody, ATG18A antibody, FLJ10055 antibody, WD repeat domain phosphoinositide interacting 1 antibody, WD repeat domain phosphoinositide interacting protein 1 antibody, WD repeat domain phosphoinositide-interacting protein 1 antibody, WD40 repeat protein interacting with phosphoinositides of 49 kDa antibody, WD40 repeat protein interacting with phosphoInositides of 49 kDa antibody, WIPI 1 alpha antibody, WIPI 1 antibody, WIPI 49 antibody, WIPI 49 kDa antibody, WIPI-1 antibody, wipi1 antibody, WIPI1_HUMAN antibody, WIPI49 antibody

UniProt: Q5MNZ9

Pathways: Nuclear Hormone Receptor Binding, ER-Nucleus Signaling