XBP1 antibody (AA 1-167)

Catalog No. ABIN7175883

The Rabbit Polyclonal anti-XBP1 antibody has been validated for ELISA, IHC and IF. It is suitable to detect XBP1 in samples from Human.

Quick Overview for XBP1 antibody (AA 1-167) (ABIN7175883)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XBP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-XBP1 Antibody

Binding Specificity: AA 1-167

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human X-box-binding protein 1 protein (1-167AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Alternative Name: XBP1

Background:

Background: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).

Aliases: Tax responsive element binding protein 5 antibody, Tax-responsive element-binding protein 5 antibody, TREB5 antibody, X box binding protein 1 antibody, X box binding protein 2 antibody, X-box-binding protein 1 antibody, XBP 1 antibody, XBP-1 antibody, XBP1 antibody, XBP1_HUMAN antibody, XBP2 antibody

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response