XAF1 antibody (AA 172-259)

Catalog No. ABIN7175921

This Rabbit Polyclonal antibody specifically detects XAF1 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for XAF1 antibody (AA 172-259) (ABIN7175921)

Target: XAF1 (XiAP Associated Factor 1 (XAF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XAF1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-XAF1 Antibody

Binding Specificity: AA 172-259

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human XIAP-associated factor 1 protein (172-259AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for XAF1

Target: XAF1 (XiAP Associated Factor 1 (XAF1))

Alternative Name: XAF1

Background:

Background: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

Aliases: BIRC 4 binding protein antibody, BIRC4 binding protein antibody, BIRC4-binding protein antibody, BIRC4BP antibody, HSXIAPAF 1 antibody, HSXIAPAF1 antibody, XAF 1 antibody, XAF1 antibody, XAF1_HUMAN antibody, XIAP associated factor 1 antibody, XIAP-associated factor 1 antibody, XIAPAF1 antibody

UniProt: Q6GPH4