GLIS2 antibody (AA 332-505)

Catalog No. ABIN7176582

The Rabbit Polyclonal anti-GLIS2 antibody has been validated for ELISA, IHC and IF. It is suitable to detect GLIS2 in samples from Human.

Quick Overview for GLIS2 antibody (AA 332-505) (ABIN7176582)

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLIS2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GLIS2 Antibody

Binding Specificity: AA 332-505

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Zinc finger protein GLIS2 protein (332-505AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GLIS2

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Alternative Name: GLIS2

Background:

Background: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).

Aliases: FLJ38247 antibody, GLI similar 2 antibody, GLI-similar 2 antibody, GLIS 2 antibody, GLIS family zinc finger 2 antibody, glis2 antibody, GLIS2_HUMAN antibody, Kruppel like zinc finger protein GLIS2 antibody, Neuronal Krueppel-like protein antibody, Zinc finger protein GLIS2 antibody

UniProt: Q9BZE0