MMP13 antibody (AA 105-472) (HRP)

Catalog No. ABIN7177116

The Rabbit Polyclonal anti-MMP13 antibody has been validated for ELISA. It is suitable to detect MMP13 in samples from Mouse.

Quick Overview for MMP13 antibody (AA 105-472) (HRP) (ABIN7177116)

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP13 antibody is conjugated to HRP

Application: ELISA

Product Details anti-MMP13 Antibody (HRP)

Binding Specificity: AA 105-472

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Collagenase 3 protein (105-472AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MMP13

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Alternative Name: Mmp13

Background:

Background: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Aliases: Mmp13 antibody, Collagenase 3 antibody, EC 3.4.24.- antibody, Matrix metalloproteinase-13 antibody, MMP-13 antibody

UniProt: P33435