GZMA antibody (AA 29-260)

Catalog No. ABIN7177245

The Rabbit Polyclonal anti-GZMA antibody has been validated for WB and ELISA. It is suitable to detect GZMA in samples from Mouse.

Quick Overview for GZMA antibody (AA 29-260) (ABIN7177245)

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMA antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GZMA Antibody

Binding Specificity: AA 29-260

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Granzyme A protein (29-260AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Alternative Name: Gzma

Background:

Background: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after \\\'Lys-31\\\' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after \\\'Lys-189\\\', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity).

Aliases: Gzma antibody, Ctla-3 antibody, Ctla3 antibody, Mtsp-1 antibody, Granzyme A antibody, EC 3.4.21.78 antibody, Autocrine thymic lymphoma granzyme-like serine protease antibody, CTLA-3 antibody, Fragmentin-1 antibody, T cell-specific serine protease 1 antibody, TSP-1 antibody

UniProt: P11032

Pathways: Apoptosis