IRF8 antibody (AA 1-424) (Biotin)

Catalog No. ABIN7177346

This Rabbit Polyclonal antibody specifically detects IRF8 in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for IRF8 antibody (AA 1-424) (Biotin) (ABIN7177346)

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF8 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-IRF8 Antibody (Biotin)

Binding Specificity: AA 1-424

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Interferon regulatory factor 8 protein (1-424AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IRF8

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Alternative Name: Irf8

Background:

Background: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5\'-TGAnTCA/GAAA-3\'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes.

Aliases: Irf8 antibody, Icsbp antibody, Icsbp1 antibody, Interferon regulatory factor 8 antibody, IRF-8 antibody, Interferon consensus sequence-binding protein antibody, ICSBP antibody

UniProt: P23611

Pathways: Cellular Response to Molecule of Bacterial Origin