LOXL2 antibody (AA 26-776) (Biotin)
Quick Overview for LOXL2 antibody (AA 26-776) (Biotin) (ABIN7177406)
Target
See all LOXL2 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 26-776
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Cross-Reactivity
- Mouse
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Purification
- >95%, Protein G purified
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Immunogen
- Recombinant Mouse Lysyl oxidase homolog 2 protein (26-776AA)
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Isotype
- IgG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))
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Alternative Name
- Loxl2
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Background
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Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys-4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 By similarity. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
Aliases: Loxl2Lysyl oxidase homolog 2 antibody, EC 1.4.3.13 antibody, Lysyl oxidase-like protein 2 antibody
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UniProt
- P58022
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Pathways
- Chromatin Binding
Target
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