P4HB antibody (AA 20-509) (HRP)

Catalog No. ABIN7177785

The Rabbit Polyclonal anti-P4HB antibody has been validated for ELISA. It is suitable to detect P4HB in samples from Mouse.

Quick Overview for P4HB antibody (AA 20-509) (HRP) (ABIN7177785)

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P4HB antibody is conjugated to HRP

Application: ELISA

Product Details anti-P4HB Antibody (HRP)

Binding Specificity: AA 20-509

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Protein disulfide-isomerase protein (20-509AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for P4HB

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Alternative Name: P4hb

Background:

Background: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP

Aliases: P4hb antibody, Pdia1Protein disulfide-isomerase antibody, PDI antibody, EC 5.3.4.1 antibody, Cellular thyroid hormone-binding protein antibody, Endoplasmic reticulum resident protein 59 antibody, ER protein 59 antibody, ERp59 antibody, Prolyl 4-hydroxylase subunit beta antibody, p55 antibody

UniProt: P09103

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism