CD8 alpha antibody (APC)

Catalog No. ABIN7178433

The Mouse Monoclonal anti-CD8 alpha antibody has been validated for FACS, IF and ELISA. It is suitable to detect CD8 alpha in samples from Human.

Quick Overview for CD8 alpha antibody (APC) (ABIN7178433)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is conjugated to APC

Application: Flow Cytometry (FACS), Immunofluorescence (IF), ELISA

Product Details anti-CD8 alpha Antibody (APC)

Cross-Reactivity: Human

Purification: Affinity purified

Immunogen: Recombinant Protein

Isotype: IgG1, IgG1 kappa

Application Details

Application Notes: Recommended dilution:IF:1:100-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09 % sodium azide and 0.2 % (w/v) BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8A

Background:

Background: COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.* Ratio of CD4 and CD8 is important for monitor of HIV infection.1. Engleman EG et al. (1981) J Exp Med 153: 193-198.2. Haynes, B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.4. Bikah G. et al. (1996). Science  274:1906.

Aliases: N/A

UniProt: P01732

Pathways: TCR Signaling