Lipocalin 2 antibody (AA 1-198) (FITC)

Catalog No. ABIN7178923

This anti-Lipocalin 2 antibody is a Rabbit Polyclonal antibody detecting Lipocalin 2 in . Suitable for Rat.

Quick Overview for Lipocalin 2 antibody (AA 1-198) (FITC) (ABIN7178923)

Target: Lipocalin 2 (LCN2)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lipocalin 2 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-Lipocalin 2 Antibody (FITC)

Binding Specificity: AA 1-198

Cross-Reactivity: Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Rat Lcn2 protein (1-198AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Lipocalin 2

Target: Lipocalin 2 (LCN2)

Alternative Name: Lcn2

Background:

Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (By similarity). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity, limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis (By similarity).

Aliases: Lcn2 antibody, Neutrophil gelatinase-associated lipocalin antibody, NGAL antibody, Alpha-2-microglobulin-related protein antibody, Alpha-2U globulin-related protein antibody, Lipocalin 24p3 antibody, Lipocalin-2 antibody, Siderocalin LCN2 antibody, p25 antibody

UniProt: P30152

Pathways: Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis