TIMP1 antibody (AA 24-217) (HRP)

Catalog No. ABIN7178944

This anti-TIMP1 antibody is a Rabbit Polyclonal antibody detecting TIMP1 in ELISA. Suitable for Rat.

Quick Overview for TIMP1 antibody (AA 24-217) (HRP) (ABIN7178944)

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-TIMP1 Antibody (HRP)

Binding Specificity: AA 24-217

Cross-Reactivity: Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Rat Metalloproteinase inhibitor 1 protein (24-217AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TIMP1

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Alternative Name: Timp1

Background:

Background: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells, procathepsin L is required for maximal activity.

Aliases: Timp1 antibody, Timp-1 antibody, Metalloproteinase inhibitor 1 antibody, Tissue inhibitor of metalloproteinases 1 antibody, TIMP-1 antibody

UniProt: P30120