TAL1 antibody (AA 1-324) (HRP)

Catalog No. ABIN7179881

This Rabbit Polyclonal antibody specifically detects TAL1 in ELISA. It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for TAL1 antibody (AA 1-324) (HRP) (ABIN7179881)

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAL1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-TAL1 Antibody (HRP)

Binding Specificity: AA 1-324

Cross-Reactivity: Zebrafish (Danio rerio)

Purification: >95%, Protein G purified

Immunogen: Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Alternative Name: tal1

Background:

Background: Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.

Aliases: tal1 antibody, scl antibody, tal-1 antibody, si:ch211-135j1.3 antibody, T-cell acute lymphocytic leukemia protein 1 homolog antibody, TAL-1 antibody, Stem cell protein antibody, zSCL antibody

UniProt: O93507

Pathways: Stem Cell Maintenance