TAL1 antibody
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- Target See all TAL1 Antibodies
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
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Reactivity
- Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TAL1 antibody is un-conjugated
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Application
- Immunofluorescence (IF), Immunohistochemistry (IHC)
- Cross-Reactivity
- Rat
- Purification
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse Tal1
- Top Product
- Discover our top product TAL1 Primary Antibody
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anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (C-Term) antibody
TAL1 Reactivity: Human, Dog, Cow, Guinea Pig, Horse, Rabbit, Pig, Monkey, Bat WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (C-Term) antibodyTAL1 Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) antibodyTAL1 Reactivity: Human WB, FACS, IF Host: Mouse Monoclonal 4G10 unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (AA 1-114) antibodyTAL1 Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (C-Term) antibodyTAL1 Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (AA 154-188) antibodyTAL1 Reactivity: Human WB Host: Rabbit Polyclonal RB50954 unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (AA 68-97) antibodyTAL1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB15312 unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (AA 236-285) antibodyTAL1 Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Pig, Monkey, Bat, Hamster WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (N-Term) antibodyTAL1 Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Pig WB Host: Rabbit Polyclonal unconjugated
anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (acLys221), (acLys222), (acLys36), (acLys37) antibodyTAL1 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- IHC/IF (R) 1:800-1:1500/1:400-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
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- Target
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
- Alternative Name
- Tal1 (TAL1 Products)
- Synonyms
- SCL/tal-1 antibody, Scl antibody, bHLHa17 antibody, tal-1 antibody, SCL antibody, TCL5 antibody, scl antibody, tcl5 antibody, SCL-alpha antibody, SCL-beta antibody, scl/tal1 antibody, zgc:85605 antibody, T cell acute lymphocytic leukemia 1 antibody, TAL bHLH transcription factor 1, erythroid differentiation factor antibody, T-cell acute lymphocytic leukemia 1 S homeolog antibody, T-cell acute lymphocytic leukemia 1 antibody, Tal1 antibody, TAL1 antibody, tal1.S antibody, tal1 antibody
- Background
- Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase alpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.
- Gene ID
- 21349
- NCBI Accession
- NP_001274317
- UniProt
- P22091
- Pathways
- Stem Cell Maintenance
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