CTNND1 antibody (Tyr228)

Catalog No. ABIN7179986

This Rabbit Polyclonal antibody specifically detects CTNND1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for CTNND1 antibody (Tyr228) (ABIN7179986)

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTNND1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CTNND1 Antibody

Binding Specificity: Tyr228

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Catenin-delta1 around the phosphorylation site of tyrosine 228 (D-N-Y(p)-G-S).

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Alternative Name: CTNND1

Background:

Background: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity. Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.Keirsebilck A., Genomics 50:129-146(1998).Nagase T., DNA Res. 4:141-150(1997).W.S., Sherwood J.K., Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.

Aliases: Cadherin associated Src substrate antibody, Cadherin-associated Src substrate antibody, CAS antibody, Catenin (cadherin associated protein) delta 1 antibody, Catenin delta 1 antibody, Catenin delta antibody, Catenin delta-1 antibody, CTND1_HUMAN antibody, CTNND 1 antibody, CTNND antibody, CTNND1 antibody, delta 1 Catenin antibody, KIAA0384 antibody, p120 antibody, P120 CAS antibody, p120 catenin antibody, P120 CTN antibody, p120(cas) antibody, p120(ctn) antibody, P120CAS antibody, P120CTN antibody

UniProt: O60716

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling