URI1 antibody (C-Term)

Catalog No. ABIN7180232

This Rabbit Polyclonal antibody specifically detects URI1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for URI1 antibody (C-Term) (ABIN7180232)

Target: URI1 (URI1, Prefoldin-Like Chaperone (URI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This URI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-URI1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human RMP.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for URI1

Target: URI1 (URI1, Prefoldin-Like Chaperone (URI1))

Alternative Name: URI1

Background:

Background: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Van Leuven F., Genomics 54:511-520(1998).
Ota T., Nat. Genet. 36:40-45(2004).
Grimwood J., Nature 428:529-535(2004).

Aliases: C19orf2 antibody, Chromosome 19 open reading frame 2 antibody, NNX3 antibody, NNX3 protein antibody, PPP1R19 antibody, Protein NNX3 antibody, Protein phosphatase 1 regulatory subunit 19 antibody, RMP antibody, RMP_HUMAN antibody, RNA polymerase II subunit 5 mediating protein antibody, RNA polymerase II subunit 5-mediating protein antibody, RPB5 mediating protein antibody, RPB5-mediating protein antibody, Unconventional prefoldin RPB5 interactor 1 antibody, Unconventional prefoldin RPB5 interactor antibody, URI antibody, URI1 antibody, URI1, prefoldin-like chaperone antibody

UniProt: O94763