GUCY1B3 antibody

Catalog No. ABIN7181380

This anti-GUCY1B3 antibody is a Rabbit Polyclonal antibody detecting GUCY1B3 in WB, ELISA, IHC and IF. Suitable for Human.

Quick Overview for GUCY1B3 antibody (ABIN7181380)

Target: GUCY1B3 (Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCY1B3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GUCY1B3 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human Guanylate Cyclase beta.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GUCY1B3

Target: GUCY1B3 (Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3))

Alternative Name: GUCY1B1

Background:

Background: This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.

A. Shimouchi, Am J Physiol Lung Cell Mol Physiol, Nov 1993, 265: 456.
Peter Sinnaeve, Circ. Res., Jan 2001, 88: 103.
Stephan Thelitz, J. Thorac. Cardiovasc. Surg., May 2004, 127: 1285 - 1292.
Richard C. Venema, Am J Physiol Heart Circ Physiol, Jul 2003, 2

Aliases: GC-S-beta-1 antibody, GC-SB3 antibody, GCbeta1 antibody, GCS beta 1 antibody, GCS beta 3 antibody, GCS-beta-1 antibody, GCS-beta-3 antibody, GCYB1_HUMAN antibody, guanylate cyclase 1, soluble, beta 3 antibody, Guanylate cyclase soluble beta 1 chain antibody, Guanylate cyclase soluble subunit beta-1 antibody, Guanylate cyclase soluble subunit beta-3 antibody, GUC1B3 antibody, GUCSB3 antibody, GUCY1B1 antibody, Gucy1b1, antibody, GUCY1B3 antibody, SGC antibody, Soluble guanylate cyclase small subunit antibody

UniProt: Q02153

Pathways: Transition Metal Ion Homeostasis