SMC3 antibody (AA 951-1050) (HRP)

Catalog No. ABIN713975

The Rabbit Polyclonal anti-SMC3 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect SMC3 in samples from Human.

Quick Overview for SMC3 antibody (AA 951-1050) (HRP) (ABIN713975)

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC3 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SMC3 Antibody (HRP)

Binding Specificity: AA 951-1050

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SMC3/CSPG6

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SMC3

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Alternative Name: SMC3

Background:

Synonyms: BAM, Bamacan, Basement membrane associated chondroitin proteoglycan, Basement membrane-associated chondroitin proteoglycan, BMH, CDLS3, chondroitin sulfate proteoglycan 6 bamacan, Chondroitin sulfate proteoglycan 6, Chromosome associated polypeptide, Chromosome-associated polypeptide, CSPG 6, CSPG6, hCAP, SMC 3, SMC protein 3, SMC-3, smc3, SMC3_HUMAN, SMC3L1, Structural maintenance of chromosome 3, Structural maintenance of chromosomes 3, Structural maintenance of chromosomes protein 3.

Background: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.

Gene ID: 9126

Pathways: Stem Cell Maintenance