S1A1 antibody

Catalog No. ABIN7182653

Product Details

Target: S1A1

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human S100 A1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: S1A1

Background:

Background: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Patrick Most, J. Biol. Chem., Nov 2003, 278: 48404 - 48412.
Miki Okada, J. Biol. Chem., Feb 2004, 279: 4221 - 4233.
Melanie Boerries, Mol. Cell. Biol., Jun 2007, 27: 4365 - 4373.
Patrick Most, J. Clin. Invest., Dec 2004, 114: 1550 - 1563.

Aliases: Bpb antibody, NEF antibody, Protein S100-A1 antibody, S-100 protein alpha chain antibody, S-100 protein subunit alpha antibody, S100 alpha antibody, S100 beta antibody, S100 calcium binding protein A1 antibody, S100 calcium binding protein B antibody, S100 calcium-binding protein A1 antibody, S100 protein alpha polypeptide antibody, S100A antibody, s100a1 antibody, S100B antibody, S100beta antibody, S10A1_HUMAN antibody

UniProt: P23297