CCAR2 antibody

Catalog No. ABIN7183705

This anti-CCAR2 antibody is a Rabbit Polyclonal antibody detecting CCAR2 in WB and ELISA. Suitable for Human.

Quick Overview for CCAR2 antibody (ABIN7183705)

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCAR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CCAR2 Antibody

Purpose: CCAR2 Antibody

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human KIAA1967.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CCAR2

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Alternative Name: CCAR2

Background:

Background: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.

Nagase T., DNA Res. 8:319-327(2001).
Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).
Olsen J.V., Cell 127:635-648(2006).

Aliases: CCAR2 antibody, DBC1 antibody, KIAA1967Cell cycle and apoptosis regulator protein 2 antibody, Cell division cycle and apoptosis regulator protein 2 antibody, DBIRD complex subunit KIAA1967 antibody, Deleted in breast cancer gene 1 protein antibody, DBC-1 antibody, DBC.1 antibody, NET35 antibody, p30 DBC antibody

UniProt: Q8N163