POLR3D antibody

Catalog No. ABIN7184078

This Rabbit Polyclonal antibody specifically detects POLR3D in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for POLR3D antibody (ABIN7184078)

Target: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR3D antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-POLR3D Antibody

Purpose: POLR3D Antibody

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human RPC4.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for POLR3D

Target: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Alternative Name: POLR3D

Background:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity.

Ittmann M., Mol. Cell. Biol. 7:3386-3393(1987).
Hu P., Mol. Cell. Biol. 22:8044-8055(2002).
Kalnine N., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

Aliases: POLR3D antibody, BN51 antibody, BN51T antibody, DNA-directed RNA polymerase III subunit RPC4 antibody, RNA polymerase III subunit C4 antibody, DNA-directed RNA polymerase III subunit D antibody, Protein BN51 antibody, RNA polymerase III 47 kDa subunit antibody, RPC53 homolog antibody

UniProt: P05423