CHP antibody (N-Term)

Catalog No. ABIN7184426

This Rabbit Polyclonal antibody specifically detects CHP in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for CHP antibody (N-Term) (ABIN7184426)

Target: CHP (Calcium Binding Protein P22 (CHP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CHP Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human CHP.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHP

Target: CHP (Calcium Binding Protein P22 (CHP))

Alternative Name: CHP1

Background:

Background: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na+/H+ exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH . Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na+/H+ exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Lin X., Proc. Natl. Acad. Sci. U.S.A. 93:12631-12636(1996).
Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T., Nat. Genet. 36:40-45(2004).

Aliases: Calcineurin B homolog antibody, Calcineurin B homologous protein antibody, Calcineurin homologous protein antibody, Calcineurin like EF hand protein 1 antibody, Calcium binding protein CHP antibody, Calcium binding protein p22 antibody, Calcium-binding protein CHP antibody, Calcium-binding protein p22 antibody, chp antibody, CHP1_HUMAN antibody, Sid 470 antibody, Sid470 antibody, SLC9A1 binding protein antibody, SLC9A1BP antibody, Wrch2 antibody

UniProt: Q99653

Pathways: Proton Transport, Regulation of Carbohydrate Metabolic Process, VEGF Signaling