CNOT7 antibody (N-Term)

Catalog No. ABIN7184433

The Rabbit Polyclonal anti-CNOT7 antibody has been validated for WB and ELISA. It is suitable to detect CNOT7 in samples from Human.

Quick Overview for CNOT7 antibody (N-Term) (ABIN7184433)

Target: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7 (CNOT7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CNOT7 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human CNOT7.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CNOT7

Target: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7 (CNOT7))

Alternative Name: CNOT7

Background:

Background: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Bogdan J.A., Biochem. J. 336:471-481(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Aliases: BTG1 binding factor 1 antibody, BTG1-binding factor 1 antibody, CAF 1 antibody, CAF-1 antibody, CAF1 antibody, Carbon catabolite repressor protein (CCR4) associative factor 1 antibody, CCR4 associated factor 1 antibody, CCR4 NOT transcription complex subunit 7 antibody, CCR4-associated factor 1 antibody, CCR4-NOT transcription complex subunit 7 antibody, CNOT 7 antibody, Cnot7 antibody, CNOT7_HUMAN antibody, hCAF 1 antibody, hCAF1 antibody

UniProt: Q9UIV1

Pathways: Ribonucleoprotein Complex Subunit Organization