SLC8A2 antibody

Catalog No. ABIN7192526

The Rabbit Polyclonal anti-SLC8A2 antibody is suitable to detect SLC8A2 in samples from Human. It has been validated for ELISA and IHC.

Quick Overview for SLC8A2 antibody (ABIN7192526)

Target: SLC8A2 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 2 (SLC8A2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC8A2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-SLC8A2 Antibody

Purpose: SLC8A2 Antibody

Cross-Reactivity: Rat

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human SLC8A2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:  pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SLC8A2

Target: SLC8A2 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 2 (SLC8A2))

Alternative Name: SLC8A2

Background:

Background: Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.

Aliases: SLC8A2 antibody, KIAA1087 antibody, NCX2 antibody, Sodium/calcium exchanger 2 antibody, Na(+)/Ca(2+)-exchange protein 2 antibody, Solute carrier family 8 member 2 antibody

UniProt: Q9UPR5