Macrophage Scavenger Receptor 1 antibody (AA 275-451)

Catalog No. ABIN7193254

This Mouse Monoclonal antibody specifically detects Macrophage Scavenger Receptor 1 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for Macrophage Scavenger Receptor 1 antibody (AA 275-451) (ABIN7193254)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Macrophage Scavenger Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 5B8H4

Product Details anti-Macrophage Scavenger Receptor 1 Antibody

Binding Specificity: AA 275-451

Purpose: CD204 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD204 (AA: 275-451) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: CD204

Background:

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Molecular Weight: 49.8 kDa

Gene ID: 4481

UniProt: P21757