LRP6 antibody (AA 1198-1370)

Catalog No. ABIN7193277

This anti-LRP6 antibody is a Mouse Monoclonal antibody detecting LRP6 in ELISA and FACS. Suitable for Human.

Quick Overview for LRP6 antibody (AA 1198-1370) (ABIN7193277)

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LRP6 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 1A3F5

Product Details anti-LRP6 Antibody

Binding Specificity: AA 1198-1370

Purpose: LRP6 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human LRP6 (AA: 1198-1370) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for LRP6

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Alternative Name: LRP6

Background:

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Molecular Weight: 180 kDa

UniProt: O75581

Pathways: WNT Signaling, Tube Formation