Rubicon antibody (AA 859-972)

Catalog No. ABIN7193445

This anti-Rubicon antibody is a Mouse Monoclonal antibody detecting Rubicon in ELISA. Suitable for Human.

Quick Overview for Rubicon antibody (AA 859-972) (ABIN7193445)

Target: Rubicon (KIAA0226) (KIAA0226)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Rubicon antibody is un-conjugated

Application: ELISA

Clone: 4F5B5

Product Details anti-Rubicon Antibody

Binding Specificity: AA 859-972

Purpose: RUBCN Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human RUBCN (AA: 859-972) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Rubicon

Target: Rubicon (KIAA0226) (KIAA0226)

Alternative Name: RUBCN

Background:

The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Molecular Weight: 108.6 kDa

Gene ID: 9711

UniProt: Q92622

Pathways: Autophagy