IL-10RA antibody (AA 22-235)

Catalog No. ABIN7193872

This Mouse Monoclonal antibody specifically detects IL-10RA in ELISA, FACS and ICC. It exhibits reactivity toward Human.

Quick Overview for IL-10RA antibody (AA 22-235) (ABIN7193872)

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-10RA antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 8A2A5

Product Details anti-IL-10RA Antibody

Binding Specificity: AA 22-235

Purpose: CD210 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD210 (AA: 22-235)) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/25 - 1/200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for IL-10RA

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Alternative Name: CD210

Background:

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Molecular Weight: 63 kDa

Gene ID: 3587

UniProt: Q13651

Pathways: Growth Factor Binding