MLL/KMT2A antibody (AA 150-400)

Catalog No. ABIN7193894

The Mouse Monoclonal anti-MLL/KMT2A antibody has been validated for IHC, ELISA, FACS and ICC. It is suitable to detect MLL/KMT2A in samples from Human.

Quick Overview for MLL/KMT2A antibody (AA 150-400) (ABIN7193894)

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MLL/KMT2A antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 7E1D10

Product Details anti-MLL/KMT2A Antibody

Binding Specificity: AA 150-400

Purpose: KMT2A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human KMT2A (AA:150-400) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for MLL/KMT2A

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Alternative Name: KMT2A

Background:

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Molecular Weight: 431 kDa

Gene ID: 4297

UniProt: Q03164

Pathways: Warburg Effect