CD28 antibody (PE)

Catalog No. ABIN7200527

This Mouse Monoclonal antibody specifically detects CD28 in FACS. It exhibits reactivity toward Human.

Quick Overview for CD28 antibody (PE) (ABIN7200527)

Target: CD28

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD28 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: C-B281

Product Details anti-CD28 Antibody (PE)

Purpose: CD28 PE Antibody

Characteristics: The clone C-B281, a mouse monoclonal antibody selectively recognizes a 44 kDa type I cell surface glycoprotein known as CD28. It is expressed by all T cells and acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, B7-1 (CD80) and B7-2 (CD86), which are primarily expressed by the activated B cells as well as other antigen-presenting cells. CD28-CD28 ligands signaling induces TCR functional activation resulting T cell proliferation, production of higher levels of IL-2 and enhancing T cell cytotoxicity.

Purification: Purified

Purity: >95 %

Immunogen: Recombinant human CD28 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD28

Target: CD28

Alternative Name: CD28

Gene ID: 940

UniProt: P10747

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response