CD8 alpha antibody

Catalog No. ABIN7200647

This Mouse Monoclonal antibody specifically detects CD8 alpha in FACS. It exhibits reactivity toward Human.

Quick Overview for CD8 alpha antibody (ABIN7200647)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is un-conjugated

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: SK1

Product Details anti-CD8 alpha Antibody

Purpose: CD8a Unconjugated Antibody

Characteristics: The clone SK1 specifically binds with a 32-34 kDa type I transmembrane glycoprotein of human cells commonly known as CD8a.  It is a member of immunoglobulin superfamily.  The CD8α forms either a homodimer (2 alpha chains) or a heterodimer with CD8β and is expressed on the surface of cytotoxic T cells, and sub-sets of NK cells, cortical thymocytes, and also on some dendritic cells. CD8 functions as a co-receptor for T cell receptor and specifically binds to class I MHC for antigen recognition and T cell activation. It has the cross-reactive binding affinity with the CD8 cell surface antigen expressing in several non-human primates, including Baboon, Chimpanzee, Cynomolgus and Rhesus.

Purification: Purified

Purity: >95 %

Immunogen: Human peripheral blood T lymphocytes

Isotype: IgG1, kappa

Application Details

Application Notes: Each lot of these antibodies has been pre-titrated and tested by flow cytometric analysis of human PBMCs such that 0.5µg (unconjugated) of these products are sufficient for staining 1 million cells in a 100µl staining volume or 100µl of whole blood. It is recommended to titrate antibody reactivity empirically for optimal performance.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8a

Gene ID: 925

NCBI Accession: NM_001768

UniProt: P01732

Pathways: TCR Signaling