AKAP13 antibody (AA 690-770)

Catalog No. ABIN7219274

This Rabbit Polyclonal antibody specifically detects AKAP13 in WB, ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for AKAP13 antibody (AA 690-770) (ABIN7219274)

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AKAP13 Antibody

Binding Specificity: AA 690-770

Purpose: AKAP 13 Polyclonal Antibody

Specificity: AKAP 13 Polyclonal Antibody detects endogenous levels of AKAP 13 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human AKAP 13 at AA range: 690-770

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for AKAP13

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Alternative Name: AKAP 13

Background: Rabbit Anti-AKAP 13 Polyclonal Antibody,AKAP13, BRX, HT31, LBC, A-kinase anchor protein 13, AKAP-13, AKAP-Lbc, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, Human thyroid-anchoring protein 31, Lymphoid blast crisis oncogene, LBC,The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.,A-kinase anchor protein 13

Gene ID: 11214

UniProt: Q12802

Pathways: Neurotrophin Signaling Pathway