ABL1/2 antibody

Catalog No. ABIN7213438

The Rabbit Polyclonal anti-ABL1/2 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect ABL1/2 in samples from Human and Mouse.

Quick Overview for ABL1/2 antibody (ABIN7213438)

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABL1/2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ABL1/2 Antibody

Purpose: Abl1/2 Polyclonal Antibody

Specificity: Abl1/2 Polyclonal Antibody detects endogenous levels of Abl1/2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Abl1/2 around the non-phosphorylation site of Y393/439

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for ABL1/2

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Alternative Name: Abl1/2

Background: Rabbit Anti-Abl1/2 Polyclonal Antibody,ABL1, ABL, JTK7, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL2, ABLL, ARG, Abelson tyrosine-protein kinase 2, Abelson murine leukemia vira,ABL1 is a protooncogene that encodes a protein tyrosine kinase (ABL proto-oncogene 1, non-receptor tyrosine kinase) involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. ABL1 has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9,22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR, MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.,Tyrosine-protein kinase ABL1

Gene ID: 25, 27