Amphiregulin antibody (Internal Region)

Catalog No. ABIN7218784

This anti-Amphiregulin antibody is a Rabbit Polyclonal antibody detecting Amphiregulin in WB and ELISA. Suitable for Human.

Quick Overview for Amphiregulin antibody (Internal Region) (ABIN7218784)

Target: Amphiregulin (AREG)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiregulin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Amphiregulin Antibody

Binding Specificity: Internal Region

Purpose: Amphiregulin Polyclonal Antibody

Specificity: Amphiregulin Polyclonal Antibody detects endogenous levels of Amphiregulin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Amphiregulin

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: Amphiregulin

Background: Rabbit Anti-Amphiregulin Polyclonal Antibody,AREG, SDGF, AREGB, Amphiregulin, AR, Colorectum cell-derived growth factor, CRDGF,The amphiregulin encoded by AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.,Amphiregulin

Gene ID: 374, 727738

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway