APLP2 antibody (pTyr755)

Catalog No. ABIN7221604

This anti-APLP2 antibody is a Rabbit Polyclonal antibody detecting APLP2 in ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for APLP2 antibody (pTyr755) (ABIN7221604)

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APLP2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APLP2 Antibody

Binding Specificity: pTyr755

Purpose: APLP2 (phospho Tyr755) Polyclonal Antibody

Specificity: Phospho-APLP2 (Y755) Polyclonal Antibody detects endogenous levels of APLP2 protein only when phosphorylated at Y755.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human APLP2 Phospho-Tyr755

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for APLP2

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Alternative Name: APLP2

Background: Rabbit Anti-APLP2 (phospho Tyr755) Polyclonal Antibody,APLP2, APPL2, Amyloid-like protein 2, APLP-2, APPH, Amyloid protein homolog, CDEI box-binding protein, CDEBP,APLP2 encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. Amyloid-like protein 2 is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.,Amyloid-like protein 2

Gene ID: 334

UniProt: Q06481

Pathways: EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Feeding Behaviour