BCCIP antibody (AA 60-140)

Catalog No. ABIN7223664

This Rabbit Polyclonal antibody specifically detects BCCIP in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for BCCIP antibody (AA 60-140) (ABIN7223664)

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCCIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BCCIP Antibody

Binding Specificity: AA 60-140

Purpose: TOK-1 Polyclonal Antibody

Specificity: TOK-1 Polyclonal Antibody detects endogenous levels of TOK-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human TOK-1 at AA range: 60-140

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for BCCIP

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Alternative Name: TOK-1

Background: Rabbit Anti-TOK-1 Polyclonal Antibody,BCCIP, TOK1, BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, Protein TOK-1,BCCIP (BRCA2 and CDKN1A interacting protein) product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for BCCIP.,BRCA2 and CDKN1A-interacting protein

Molecular Weight: observerd band 35kDa

Gene ID: 56647

UniProt: Q9P287