C1r HC (AA 390-470), (Cleaved-Arg463) antibody

Catalog No. ABIN7224738

This anti-C1r HC antibody is a Rabbit Polyclonal antibody detecting C1r HC in ELISA and WB. Suitable for Human.

Quick Overview for C1r HC (AA 390-470), (Cleaved-Arg463) antibody (ABIN7224738)

Target: C1r HC

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 390-470, Cleaved-Arg463

Purpose: Cleaved-C1r HC (R463) Polyclonal Antibody

Specificity: Cleaved-C1r HC (R463) Polyclonal Antibody detects endogenous levels of fragment of activated C1r HC protein resulting from cleavage adjacent to R463.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human C1r HC at AA range: 390-470

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: C1r HC

Background: Rabbit Anti-Cleaved-C1r HC (R463) Polyclonal Antibody,C1R, Complement C1r subcomponent, Complement component 1 subcomponent r,The first component of complement is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. The serine protease subunits C1r and C1s form a Ca(2+)-dependent C1s-C1r-C1r-C1s tetramer. C1r acts by transforming the activation signal into an enzymic activity. C1r is a single-chain glycoprotein which can be cleaved into an A chain and a B chain upon activation. This antibody recognizes full-length C1r chain and the cleaved B chain.,Complement C1r subcomponent

Molecular Weight: observerd band 51kDa

Gene ID: 715

UniProt: P00736