C1r LC (AA 420-500), (Cleaved-Ile464) antibody

Catalog No. ABIN7212430

This Rabbit Polyclonal antibody specifically detects C1r LC in ELISA and WB. It exhibits reactivity toward Human.

Quick Overview for C1r LC (AA 420-500), (Cleaved-Ile464) antibody (ABIN7212430)

Target: C1r LC

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 420-500, Cleaved-Ile464

Purpose: Cleaved-C1r LC (I464) Polyclonal Antibody

Specificity: Cleaved-C1r LC (I464) Polyclonal Antibody detects endogenous levels of fragment of activated C1r LC protein resulting from cleavage adjacent to I464.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human C1r LC at AA range: 420-500

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: C1r LC

Background: Rabbit Anti-Cleaved-C1r LC (I464) Polyclonal Antibody,C1R, Complement C1r subcomponent, Complement component 1 subcomponent r,C1R (Complement C1r Subcomponent) is a Protein Coding gene. Diseases associated with C1R include immunodeficiency due to an early component of complement deficiency and c1r/c1s deficiency, combined. Among its related pathways are Complement and coagulation cascades and Immune System. GO annotations related to C1R include calcium ion binding and serine-type peptidase activity. An important paralog of C1R is HP.C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.C1R aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of C1R was annotated on NT_009714.18 and the 3' end was annotated on NT_009759.17 in NCBI's Homo sapiens Annotation Release 106.,Complement C1r subcomponent

Molecular Weight: observerd band 27kDa

Gene ID: 715

UniProt: P00736