C1r LC (AA 420-500), (Cleaved-Ile464) antibody

Catalog No. ABIN7212430

This Rabbit Polyclonal antibody specifically detects C1r LC in ELISA and WB. It exhibits reactivity toward Human.

Quick Overview for C1r LC (AA 420-500), (Cleaved-Ile464) antibody (ABIN7212430)

Target: C1r LC

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 420-500, Cleaved-Ile464

Purpose: Rabbit Anti-Cleaved-C1r LC (I464) Polyclonal Antibody

Specificity: Cleaved-C1r LC (I464) Polyclonal Antibody detects endogenous levels of fragment of activated C1r LC protein resulting from cleavage adjacent to I464.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human C1r LC at AA range: 420-500

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details

Target: C1r LC

Background: C1R, Complement C1r subcomponent, Complement component 1 subcomponent rC1R (Complement C1r Subcomponent) is a Protein Coding gene. Diseases associated with C1R include immunodeficiency due to an early component of complement deficiency and c1r/c1s deficiency, combined. Among its related pathways are Complement and coagulation cascades and Immune System. GO annotations related to C1R include calcium ion binding and serine-type peptidase activity. An important paralog of C1R is HP.C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.C1R aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of C1R was annotated on NT_009714.18 and the 3' end was annotated on NT_009759.17 in NCBI's Homo sapiens Annotation Release 106.

Molecular Weight: 27kD

Gene ID: 715

UniProt: P00736