CAPN10 antibody (N-Term)

Catalog No. ABIN7219246

This Rabbit Polyclonal antibody specifically detects CAPN10 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for CAPN10 antibody (N-Term) (ABIN7219246)

Target: CAPN10 (Calpain 10 (CAPN10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAPN10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CAPN10 Antibody

Binding Specificity: N-Term

Purpose: Calpain 10 Polyclonal Antibody

Specificity: Calpain 10 Polyclonal Antibody detects endogenous levels of Calpain 10 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the N-terminal region of human Calpain 10

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CAPN10

Target: CAPN10 (Calpain 10 (CAPN10))

Alternative Name: Calpain 10

Background: Rabbit Anti-Calpain 10 Polyclonal Antibody,CAPN10, KIAA1845, Calpain-10, Calcium-activated neutral proteinase 10, CANP 10,Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. CAPN10 encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. CAPN10 is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.,Calpain-10

Molecular Weight: observerd band 75kDa

Gene ID: 11132

UniProt: Q9HC96

Pathways: Positive Regulation of Peptide Hormone Secretion