CPE antibody (AA 240-320)

Catalog No. ABIN7214314

The Rabbit Polyclonal anti-CPE antibody has been validated for WB and ELISA. It is suitable to detect CPE in samples from Human, Mouse and Rat.

Quick Overview for CPE antibody (AA 240-320) (ABIN7214314)

Target: CPE (Carboxypeptidase E (CPE))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPE antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CPE Antibody

Binding Specificity: AA 240-320

Purpose: CPE Polyclonal Antibody

Specificity: CPE Polyclonal Antibody detects endogenous levels of CPE protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human CPE at AA range: 240-320

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CPE

Target: CPE (Carboxypeptidase E (CPE))

Alternative Name: CPE

Background: Rabbit Anti-CPE Polyclonal Antibody,CPE, Carboxypeptidase E, CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase,CPE encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. Carboxypeptidase E may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in CPE are implicated in type 2 diabetes.,Carboxypeptidase E

Molecular Weight: observerd band 53kDa

Gene ID: 1363

UniProt: P16870

Pathways: Peptide Hormone Metabolism, Synaptic Membrane