Caspase 2 p18 antibody (Cleaved-Thr325)

Catalog No. ABIN7225274

The Rabbit Polyclonal anti-Caspase 2 p18 antibody has been validated for WB and ELISA. It is suitable to detect Caspase 2 p18 in samples from Human, Mouse and Rat.

Quick Overview for Caspase 2 p18 antibody (Cleaved-Thr325) (ABIN7225274)

Target: Caspase 2 p18

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 2 p18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Caspase 2 p18 Antibody

Binding Specificity: AA 250-330, Cleaved-Thr325

Purpose: Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody

Specificity: Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-2 p18 protein resulting from cleavage adjacent to T325.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-2 p18 at AA range: 250-330

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Caspase 2 p18

Target: Caspase 2 p18

Alternative Name: Caspase-2 p18

Background: Rabbit Anti-Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody,CASP2, ICH1, NEDD2, Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1,CASP2 (caspase 2) encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of CASP2 may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for CASP2.,Caspase-2

Molecular Weight: observerd band 22kDa

Gene ID: 835

UniProt: P42575