Caspase 6 Subunit p11 (AA 150-230), (Cleaved-Ala194) antibody

Catalog No. ABIN7226778

This Rabbit Polyclonal antibody specifically detects Caspase 6 Subunit p11 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Caspase 6 Subunit p11 (AA 150-230), (Cleaved-Ala194) antibody (ABIN7226778)

Target: Caspase 6 Subunit p11

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 150-230, Cleaved-Ala194

Purpose: Rabbit Anti-Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody

Specificity: Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-6 p11.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Cleaved-Caspase-6 p11 (A194) at AA range: 150-230

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details

Target: Caspase 6 Subunit p11

Alternative Name: Caspase-6 p11

Background: Caspase 6, apoptosis-related cysteine peptidaseCASP6 (caspase 6) encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

Molecular Weight: 33kD

Gene ID: 839

UniProt: P55212