CENPA antibody (pSer7)

Catalog No. ABIN7219060

The Rabbit Polyclonal anti-CENPA antibody (ABIN7219060) specifically detects CENPA in ELISA and IF. The antibody is reactive with Human samples.

Quick Overview for CENPA antibody (pSer7) (ABIN7219060)

Target: CENPA (Centromere Protein A (CENPA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPA antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-CENPA Antibody

Binding Specificity: pSer7

Purpose: CENP-A (phospho Ser7) Polyclonal Antibody

Specificity: Phospho-CENP-A (S7) Polyclonal Antibody detects endogenous levels of CENP-A protein only when phosphorylated at S7.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human CENP-A Phospho-Ser7

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CENPA

Target: CENPA (Centromere Protein A (CENPA))

Alternative Name: CENP-A

Background: Rabbit Anti-CENP-A (phospho Ser7) Polyclonal Antibody,CENPA, Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A,Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,Histone H3-like centromeric protein A

Gene ID: 1058

UniProt: P49450

Pathways: Chromatin Binding, Maintenance of Protein Location